Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients with Severe and Life-Threatening COVID-19. Exuberant Elevation of IP-10, MCP-3 and IL-1ra during SARS-CoV-2 Infection Is Associated with Disease Severity and Fatal Outcome. Thus, promoting the degradation of HA may be significant in the recovery process. Evidences for TRPs as medium of lung injury are emerging from studies on various inhalational chemical threats (Achanta and Jordt, 2020). COPD and asthma cause your airways to swell and become blocked with mucus, which can make it hard to breathe. However, the efficacy and safety of these drugs in COVID-19 patients are unclear. He was medicated with methylprednisolone 1 mg/kg and diuretics and recovered rapidly. 1480 (1), 73103. doi:10.1016/j.bbagen.2005.09.009, Zhuo, X.-J., Hao, Y., Cao, F., Yan, S.-F., Li, H., Wang, Q., et al. (2020). Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. J. Respir. Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors Usage Is Associated with Improved Inflammatory Status and Clinical Outcomes in COVID-19 Patients with Hypertension. Immunopharmacology and Immunotoxicology 36 (6), 420425. Chloride Transport-Driven Alveolar Fluid Secretion Is a Major Contributor to Cardiogenic Lung Edema. Clipboard, Search History, and several other advanced features are temporarily unavailable. Fatigue, headache, chills, and new or worsened muscle pain were most common. (2014). doi:10.1152/ajplung.00255.2019, Zhang, B.-M., Wang, Z.-B., Xin, P., Wang, Q.-H., Bu, H., and Kuang, H.-X. Pharmacol. Physiol. Physiol. Patients in intensive care units (ICU) have higher plasma levels of IL2, IL7, IL10, MCP1, MIP1A, GSCF, IP10, and TNF (Huang et al., 2020). Ann. doi:10.1111/j.1440-1827.2004.01754.x, Garvin, M. R., Alvarez, C., Miller, J. I., Prates, E. T., Walker, A. M., Amos, B. K., et al. (2020). (2008). doi:10.1111/bph.12414, Kaur, S. P., and Gupta, V. (2020). Front. 110 (25), E2308E2316. J. Med.